Preprint / Version 1

Most Successful Preventative Medical Interventions for Pancreatic Cancer

##article.authors##

  • Emmy Lin La Canada High School

DOI:

https://doi.org/10.58445/rars.1875

Keywords:

Pancreatic Cancer, Cancer, Biology, Treatments, Therapy

Abstract

Pancreatic cancer remains one of the deadliest cancers in the world and has continued to increase in severity among people due to the increase in the aging population, rising rates of obesity, type 2 diabetes, and etc, resulting in low survival rates and significant impacts on the quality of lives (Klein, 2021). As a result, this cancer has led to the development of many different types of treatments in order to slow down or stop the rate of pancreatic cancer from spreading or becoming severe. Some of these treatments include surgical interventions (whipple procedure, total pancreatectomy, and distal pancreatectomy), immunotherapy, chemotherapy and radiation therapy, targeted therapy, and vaccines. This study aims to evaluate the most effective therapeutic strategies for enhancing patient outcomes by evaluating comprehensive analysis on clinical data, and investigating how these strategies affect the survival rates and overall patient well-being over 3 years after getting medical intervention. From this study, it can be concluded that distal pancreatectomy is preferable compared to other medical interventions due to its balance of lower complication rates, effective pain relief, and satisfactory survival outcomes, especially for tumors that are located in the tail of the pancreas. Comparatively, other treatments, while useful in specific contexts, present a higher risk and long term complications that can affect patients’ quality of life.  

References

References

American Cancer Society. (n.d.). Targeted Drug Therapy. American Cancer Society. Retrieved October 21, 2024, from https://www.cancer.org/cancer/managing-cancer/treatment-types/targeted-therapy.html

American Cancer Society. (2024, February 5). Immunotherapy for Pancreatic Cancer | Keytruda for Pancreatic Cancer. American Cancer Society. Retrieved October 21, 2024, from https://www.cancer.org/cancer/types/pancreatic-cancer/treating/immunotherapy.html

Changazi, S. H. (2020, November 13). Whipple Procedure: A Five-Year Clinical Experience in Tertiary Care Center. Whipple Procedure: A Five-Year Clinical Experience in Tertiary Care Center. Retrieved October 21, 2024, from https://pmc.ncbi.nlm.nih.gov/articles/PMC7733773/

City of Hope. (2023, December 27). Chemoradiation: What Is It, How Is It Given & Side Effects. Cancer Treatment Centers of America. Retrieved October 21, 2024, from https://www.cancercenter.com/treatment-options/chemoradiation

Falco, M., Masojć, B., & Sulikowski, T. (2023). Radiotherapy in Pancreatic Cancer: To Whom, When, and How? National Library of Medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC10340157/

Frysh, P. (2022, November 15). What's the Difference Between Chemotherapy and Radiation? WebMD. Retrieved October 21, 2024, from https://www.webmd.com/cancer/cancer-chemotherapy-radiation-differences

Huang, X., Zhang, G., Tang, T., Gao, X., & Liang, T. (2022, October 13). Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine. PubMed. Retrieved October 21, 2024, from https://pubmed.ncbi.nlm.nih.gov/36224645/

Hutchins, R., Hart, R., Pacifico, M., Bradley, N., & Williamson, R. (2002). Long-Term Results of Distal Pancreatectomy for Chronic Pancreatitis in 90 Patients. Long-Term Results of Distal Pancreatectomy for Chronic Pancreatitis in 90 Patients. Retrieved October 21, 2024, from https://pmc.ncbi.nlm.nih.gov/articles/PMC1422619/

Klein, A. P. (2021). Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. National Library of Medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC9265847/#:~:text=Pancreatic%20cancer%20is%20a%20leading,in%20genome%2Dwide%20association%20studies

Leroux, C., & Konstantinidou, G. (2021, February 14). Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology. Home - PMC. Retrieved October 21, 2024, from https://pmc.ncbi.nlm.nih.gov/articles/PMC7918504/

National Cancer Institute. (2024, August 28). Pancreatic Cancer Treatment - NCI. National Cancer Institute. Retrieved October 21, 2024, from https://www.cancer.gov/types/pancreatic/patient/pancreatic-treatment-pdq

National Library of Medicine. (2009). Patient outcomes after total pancreatectomy: a single centre contemporary experience. Patient outcomes after total pancreatectomy: a single centre contemporary experience. Retrieved October 21, 2024, from https://pmc.ncbi.nlm.nih.gov/articles/PMC2756635/

Sheikh, Z., Ansorge, R., Wiginton, K., & Mitchell, K. (2023, December 20). Whipple Procedure: Effects, Success Rate, and More. WebMD. Retrieved October 21, 2024, from https://www.webmd.com/cancer/pancreatic-cancer/whipple-procedure

University of Utah. (2019, March 7). Why Is Pancreatic Cancer So Deadly? University of Utah Health. Retrieved October 21, 2024, from https://healthcare.utah.edu/healthfeed/2019/03/why-pancreatic-cancer-so-deadly

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Posted

2024-10-24