Neurodegenerative Disorders
Today and Tomorrow
DOI:
https://doi.org/10.58445/rars.1563Keywords:
Neurodegenerative Disorders, Alzheimer's, Parkinson's, Huntington'sAbstract
In today's growing world, neurodegenerative disorders are a major concern. While not immediately destructive as diseases like cancer, these disorders slowly affect patients and really cripple their quality of lives. This review will describe three prominent neurodegenerative disorders: Alzheimer's, Parkinson's and Huntington's Disease. The aspects described will include some background information, neuroanatomy of the disorders, current treatment methods & potential future treatments. A major focus will be given to the behavioral aspects of these disorders, so as to allow the future treatment methodologies to develop a holistic approach towards their cure. Throughout the review, it was deciphered that behavioral aspects, of the disorders described, were more or less similar, with the differences in symptoms mostly involving motor impairments of Parkinson's and Huntington's. This paper is intended to serve as a basic source of information for these diseases in the development of potential treatments for these neurodegenerative disorders.
References
Qiu, C. Kivipelto, M. Strauss, E.V. (2009). Epidemiology of Alzheimer’s disease: occurrence,
determinants, and strategies toward intervention. Dialogues in Clinical Neuroscience, 11(2),
-128. doi: 10.31887/DCNS.2009.11.2/cqiu
Terracciano, A. Sutin, A.R. (2019). Personality and Alzheimer's disease: An integrative
review. Personality disorders, 10(1), 4–12. doi: 10.1037/per0000268
Beitz, J.M. (2014). Parkinson’s Disease: a review. Frontiers in Bioscience, S6, 65-74. doi:
2741/s415
Lotankar, S. Prabhavalkar, K.S, Bhatt, L.K. (2017). Biomarkers for Parkinson’s Disease:
Recent Advancement. Neuroscience Bulletin, 33(5), 585–597. doi: 10.1007/s12264-017-0183-5
Karagas, N.E., Rocha, N.P., Stimming, E.F. (2020). Irritability in Huntington’s Disease. Journal
of Huntington’s Disease, 9, 107-113. doi: 10.3233/jhd-200397
Pohl, F. Lin, P.K.T. (2018). The Potential Use of Plant Natural Products and Plant Extracts
with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In
Vitro, In Vivo and Clinical Trials. Molecules, 23, 3283. doi: 10.3390/molecules23123283
Raji, C.A. Lopez, O.L. Kuller, L.H. Carmichael, O.T. Becker, J.T. (2009). Age, Alzheimer
disease, and brain structure. Neurology, 73(22), 1899-1905. doi:
1212/WNL.0b013e3181c3f293
Masters, C.L. Beyreuther, K. (1998). Science, medicine, and the future Alzheimer’s disease.
British Medical Journal, 316, 446–8. doi: 10.1136/bmj.316.7129.446
Paola, M.D. Spalletta, G. Caltagirone, C. (2010) In Vivo Structural Neuroanatomy of Corpus
Callosum in Alzheimer’s Disease and Mild Cognitive Impairment Using Different MRI
Techniques: A Review. Journal of Alzheimer's Disease, 20, 67-95. doi: 10.3233/JAD-2010-1370
Victoroff, J. Lin, F.V. Cobourn, K.L. Shillcutt, S.D. Boon, V. Ducharme, S. (2018).
Noncognitive Behavioral Changes Associated With Alzheimer’s Disease: Implications of
Neuroimaging Findings. Journal of Neuropsychiatry and Clinical Neuroscience, 30, 14–21. doi:
1176/appi.neuropsych.16080155
appi.neuropsych.16080155.ds001.pdf (psychiatryonline.org)
Jankovic, J. (2007). Parkinson’s disease: clinical features and diagnosis. Journal of
Neuropsychiatry and Clinical Neuroscience, 79, 368–376. doi: 10.1136/jnnp.2007.131045
Jancovic, J. Aguilar, L.G. (2008). Current approaches to the treatment of Parkinson’s
disease. Neuropsychiatric Disease and Treatment, 4(4) 743–757. doi: 10.2147/ndt.s2006
McColgan, P. Tabrizi, S.J. (2017). Huntington's disease: a clinical review. European Journal
of Neurology. 25(1), 24-34. https://doi.org/10.1111/ene.13413
Reiner, A. Dragatsis, I. Dietrich, P. (2011). Genetics and Neuropathology of Huntington's
Disease. International Review of Neurobiology, 98, 325-372. doi:
1016/B978-0-12-381328-2.00014-6
Minkova, L. Gregory, S. Scahill, R.I. Abdulkadir A. Kaller, C.P. Peter, J. Long, J.D. Stout, J.C.
Reilmann, R. Roos, R.A. Durr, A. Leavitt, B.R. Tabrizi, S.J. Klöppel, S. TRACK-HD Investigators
(2018). Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's
disease. NeuroImage: Clinical, 17, 312-324. https://doi.org/10.1016/j.nicl.2017.10.023
Anderson, K.E. Duijn, E.V. Craufurd, D. Drazinic, C. Edmondson, M. Goodman, N.
Kammen, D.V. Loy, C. Priller, J. Goodman, L.V. (2018). Clinical Management of
Neuropsychiatric Symptoms of Huntington's Disease: Expert-Based Consensus Guidelines on
Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders. Journal of Huntington’s Disease, 7,
-366. doi: 10.3233/JHD-180293
Mueller, S.M. Petersen, J.A. Jung, H.H. (2019). Exercise in Huntington’s Disease: Current
State and Clinical Significance. Tremor and Other Hyperkinetic Movements, 9. doi:
7916/tm9j-f874
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