Alzheimer′s disease and sleep: exploring the relationship between sleep disturbances and cognitive decline
DOI:
https://doi.org/10.58445/rars.151Keywords:
Alzheimer′s disease, Sleep, sleep disturbances, cognitive decline, non-pharmacological interventions, sleep hygieneAbstract
This paper explores the relationship between sleep disturbances and cognitive decline in Alzheimer's disease. Sleep disruptions have been identified as a common symptom of Alzheimer's, affecting up to 50–70% of patients. As such, due to the high rates of Alzheimer's disease in our aging population, there is an increased need to identify this relationship and potential interventions. This paper adopted an integrative review approach to achieve this goal. Findings show a strong link between sleep disturbances and Alzheimer's disease. Sleep problems were found to decrease patients' general prognosis and hasten the development of Alzheimer's disease due to rapid cognitive decline. Studies show various sleep-related problems in patients with Alzheimer's, including changes in sleep architecture, decreased sleep efficiency, increased sleep fragmentation, and disturbances in circadian rhythm. In addition, results show that sleep disturbances in Alzheimer's disease are multifactorial and include behavioral and physiological factors. The paper highlights the importance of sleep hygiene and non-pharmacological interventions for managing sleep disturbances in Alzheimer's patients. The paper also identifies the need for more research in the field, particularly in investigating the relationship between sleep disturbances and behavioral and psychological symptoms of dementia in Alzheimer's disease patients.
References
Abbott SM, Videnovic A. Chronic sleep disturbance and neural injury: links to neurodegenerative disease. Nat Sci Sleep. 2016 Jan 25;8:55-61. doi: 10.2147/NSS.S78947. PMID: 26869817; PMCID: PMC4734786.
Alzheimer's Association (2021). Alzheimer's Disease Facts and Figures. https://www.alz.org/alzheimers-dementia/facts-figures#:~:text=Quick%20Facts,-More%20than%206&text=By%202050%2C%20this%20number%20is,in%20Alzheimer's%20and%20dementia%20deaths.
Cordone S, Scarpelli S, Alfonsi V, De Gennaro L, Gorgoni M. Sleep-Based Interventions in Alzheimer's Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory. Pharmaceuticals (Basel). 2021 Apr 19;14(4):383. doi: 10.3390/ph14040383. PMID: 33921870; PMCID: PMC8073746.
Dang-Vu TT, Desseilles M, Peigneux P, Maquet P. A role for sleep in brain plasticity. Pediatr Rehabil. 2006 Apr-Jun;9(2):98-118. doi: 10.1080/13638490500138702. PMID: 16449068.
David R, Zeitzer J, Friedman L, Noda A, O'Hara R, Robert P, Yesavage JA. Non-pharmacologic management of sleep disturbance in Alzheimer's disease. J Nutr Health Aging. 2010 Mar;14(3):203-6. doi: 10.1007/s12603-010-0050-9. PMID: 20191254.
Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, McKeith IG, Thomas AJ. Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease. Psychol Med. 2021 Nov;51(15):2590-2598. doi: 10.1017/S0033291720001130. Epub 2020 May 5. PMID: 32366348.
Klinzing, J. G., Niethard, N., & Born, J. Mechanisms of systems memory consolidation during sleep. Nat Neurosci 22, 1598-1610 (2019). https://doi.org/10.1038/s41593-019-0467-3
Komaroff AL. Does Sleep Flush Wastes From the Brain? JAMA. 2021 Jun 1;325(21):2153-2155. doi: 10.1001/jama.2021.5631. PMID: 33999096.
Marde VS, Atkare UA, Gawali SV, Tiwari PL, Badole SP, Wankhede NL, Taksande BG, Upaganlawar AB, Umekar MJ, Kale MB. Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets. Asian J Psychiatr. 2022 Feb;68:102961. doi: 10.1016/j.ajp.2021.102961. Epub 2021 Dec 2. PMID: 34890930.
O'Caoimh R, Mannion H, Sezgin D, O'Donovan MR, Liew A, Molloy DW. Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: A systematic review and meta-analysis. Maturitas. 2019 Sep;127:82-94. doi: 10.1016/j.maturitas.2019.06.007. Epub 2019 Jun 21. PMID: 31351523.
Cacho, Valerie, Esther Lum, and Smita Patel (eds), 'Sleep Hygiene', in Valerie Cacho, and Esther Lum (eds), Integrative Sleep Medicine, Weil Integrative Medicine Library (New York, 2021; online edn, Oxford Academic, 1 May 2021). https://doi.org/10.1093/med/9780190885403.003.0008
Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008 Jun 11;299(22):2642-55. doi: 10.1001/jama.299.22.2642. PMID: 18544724.
Romanella SM, Roe D, Tatti E, Cappon D, Paciorek R, Testani E, Rossi A, Rossi S, Santarnecchi E. The Sleep Side of Aging and Alzheimer's Disease. Sleep Med. 2021 Jan;77:209-225. doi: 10.1016/j.sleep.2020.05.029. Epub 2020 May 30. PMID: 32912799; PMCID: PMC8364256.
Taillard, J., Sagaspe, P., Berthomier, C., Brandewinder, M., Amieva, H., Dartigues, J., Rainfray, M., Harston, S., & Philip, P. (2019). Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population. Frontiers in Neurology, 10. https://doi.org/10.3389/fneur.2019.00197
Uddin MS, Tewari D, Mamun AA, Kabir MT, Niaz K, Wahed MII, Barreto GE, Ashraf GM. Circadian and sleep dysfunction in Alzheimer's disease. Ageing Res Rev. 2020 Jul;60:101046. doi: 10.1016/j.arr.2020.101046. Epub 2020 Apr 16. PMID: 32171783.
Wolkove N, Elkholy O, Baltzan M, Palayew M. Sleep and aging: 2. Management of sleep disorders in older people. CMAJ. 2007 May 8;176(10):1449-54. doi: 10.1503/cmaj.070335. PMID: 17485699; PMCID: PMC1863539.
Zhou G, Liu S, Yu X, Zhao X, Ma L, Shan P. High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China. Medicine (Baltimore). 2019 Dec;98(50):e18405. doi: 10.1097/MD.0000000000018405. PMID: 31852160; PMCID: PMC6922506.
Downloads
Posted
Categories
License
Copyright (c) 2023 ARNAV KOLLURU
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.