Closed-Loop Deep Brain Stimulation Via High-density Nano-based Microelectrode Array Configuration for Enhanced Targeting Precision
DOI:
https://doi.org/10.58445/rars.1309Keywords:
Deep Brain Stimulation (DBS), Parkinson’s Disease (PD), Subthalamic Nucleus (STN), Microelectrode Array, Electrocorticographic (ECOG) Strip, Closed-Loop System, Neurostimulation, High-Density Electrodes, Adaptive Stimulation, NeuromodulationAbstract
Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN) is the gold standard treatment for medication-refractory Parkinson’s disease (PD), particularly in patients with debilitating motor symptoms. Our device features an adaptive closed-loop system via a high-density nano-based microelectrode array configuration and electrocorticographic (ECOG) strip. The use of a microelectrode array will maximize the precision of the area stimulated, minimizing adverse effects caused by current spread outside of the target region. Additionally, the closed-loop design will adjust stimulation patterns in real-time based on the patient's symptoms, which extends its battery life, allowing for longer periods of use before the need for replacement via reoperation. Adjustments to stimulation patterns will be monitored using an ECOG strip, which records changes in the power of beta and gamma waves, corresponding to slowness/ stiffness, and dyskinesias respectively.
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