Preprint / Version 1

A Proposal For ICD Infection Symptom Prevention Using Automated Impedance Testing Devices (AITDs)

Future of Infection Prevention of Pacemakers

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  • Nicolas Xu Tsinghua International School, Illinois Institute of Technology, University of Chicago

DOI:

https://doi.org/10.58445/rars.1248

Keywords:

Biomedical Engineering, Research Proposal, Pacemaker, ICD Infection

Abstract

Despite research and development to prevent infections and malfunctions in implantable cardioverter defibrillators (ICDs), infection rates of ICD implantations are still impactful. According to a study published on 4 Nov. 2022 by Michele Malagù et al., 1%-2% of patients who suffer from arrhythmia and resort to using ICDs (including the newest model ICD-11) have ICD infections [1]. This leads to complications, including signs of pain, erythema, swelling, or discharge on the ICD pocket site as well as fever, systematic infection, and even death if left untreated [2]. Current projects primarily focus on developing biocompatible materials, such as antibiotic-impregnated mesh to reduce the risk of infections [3]. Other studies focus on curing infections should they arise, including removal of the infected ICD [4] and antibiotics treatments that last up to 14-16 weeks [5]. However, neither cases consider the lasting effects of ICD infections on patients.

Author Biography

Nicolas Xu, Tsinghua International School, Illinois Institute of Technology, University of Chicago

Junior in Damien High School. Current intended major is Biomedical Engineering (within the Tissue engineering spectrum)

References

. Malagù, Michele, et al. “Risk Scores for Cardiac Implantable Electronic Device Infection: Which One to Believe In?” Journal of Clinical Medicine, vol. 11, no. 21, Multidisciplinary Digital Publishing Institute, Nov. 2022, p. 6556. https://doi.org/10.3390/jcm11216556.

. MY APPROACH to the Patient With an Infected Implantable Cardioverter Defibrillator (ICD).” PracticeUpdate, www.practiceupdate.com/content/my-approach-to-the-patient-with-an-infected-implantable-cardioverter-defibrillator-icd/52868.

. Barbar, Tarek, et al. “Strategies to Prevent Cardiac Implantable Electronic Device Infection.” National Library of Medicine, vol. 11, no. 1, Jan. 2020, pp. 3949–56. https://doi.org/10.19102/icrm.2020.110102.

. Povsic TJ, Najjar SS, Prather K, et al. Design and rationale of the PREDICTS study: a randomized, multicenter, clinical trial assessing superiority of preventive antibiotics versus standard of care in patients at high risk for implantable cardioverter-defibrillator infections. Am Heart J. 2016;173:95-102. doi:10.1016/j.ahj.2015.10.018

. European Consensus Document on Cardiac Implantable Electronic Device Infections - American College of Cardiology.” American College of Cardiology, 2 Mar. 2020, www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2020/03/02/13/54/European-Heart-Rhythm-Association-EHRA.

. Team, Heart and Vascular. “Is a Hidden Pacemaker Infection Making You Sick?” Cleveland Clinic, 20 Mar. 2023, health.clevelandclinic.org/is-a-hidden-pacemaker-infection-making-you-sick.

. Implantable Cardioverter-defibrillators (ICDs) - Mayo Clinic. 2 Dec. 2021, www.mayoclinic.org/tests-procedures/implantable-cardioverter-defibrillators/about/pac-20384692.

. Coxworth, Ben. “New Type of Electrotherapy Makes Implantable Defibrillators Less Shocking.” New Atlas, 2 May 2015, newatlas.com/less-shocking-implantable-defibrillators/25126.

. Kirkfeldt, Rikke Esberg. “Management of Cardiac Electronic Device Infections: Challenges and Outcomes.” Radcliffe Cardiology, Dec. 2020, www.aerjournal.com/articles/management-cardiac-electronic-device-infections-challenges-and-outcomes.

. Swerdlow, Charles D., et al. “Impedance in the Diagnosis of Lead Malfunction.” Circulation-arrhythmia and Electrophysiology, vol. 13, no. 2, Lippincott Williams and Wilkins, Feb. 2020, https://doi.org/10.1161/circep.119.008092.

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Posted

2024-06-29