Preprint / Version 1

A Review of Neurobiological Advancements in Understanding Alzheimer's Disease

##article.authors##

  • Madison Deniz Ertan Portola High School

DOI:

https://doi.org/10.58445/rars.1011

Keywords:

Alzheimer's Disease, Stem Cells, Degenerative Diseases, Amyloid Beta

Abstract

In this paper, I delve into the neurobiology of Alzheimer's disease, aiming to understand how it starts and progresses. I investigate potential ways to make the effects of this disease less visible. By keeping up with the latest in Alzheimer's research, I hope to raise awareness about promising and effective treatments to improve the lives of those grappling with this challenging brain condition. Stem cell therapy is emerging as a potential solution for Alzheimer's treatment. Overall, through my review of the published literature, I found that different types of stem cells, such as Ad-MSC, BM-MSC, hESC, iPSC, MGE progenitor cells, MSC, NSC, NPC, OEC, and UC-MSC, are being explored for their therapeutic effects. These stem cells offer benefits, including anti-inflammatory properties and regenerative capabilities. While the field is still in its early stages, the hope is that stem cell therapies could address the challenges posed by Alzheimer's. Ongoing research enhances living conditions for those who have this disease, and determines the most effective methods to administer these therapies. The exploration of stem cells for Alzheimer's reflects an area of study that may contribute to future advancements in managing this challenging neurodegenerative disease and the destructive effects for those who suffer.

References

Alipour, M., Nabavi, S. M., Arab, L., Vosough, M., Pakdaman, H., Ehsani, E., & Shahpasand, K. (2019). Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks. Molecular biology reports, 46, 1425-1446. https://doi.org/10.1007/s11033-018-4499-7

Alvarez-Erviti, L., Seow, Y., Yin, H. et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29, 341–345 (2011). https://doi.org/10.1038/nbt.1807

Alzheimer's Association. (2016). 2016 Alzheimer's disease facts and figures. Alzheimer's & Dementia, 12(4), 459-509. https://doi.org/10.1016/j.jalz.2016.03.001

Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011). Alzheimer's disease. the Lancet, 377(9770), 1019-1031. https://doi.org/10.1016/S0140-6736(10)61349-9

Bush, A. I. (2003). The metallobiology of Alzheimer's disease. Trends in neurosciences, 26(4), 207-214. https://doi.org/10.1016/S0166-2236(03)00067-5

Elovsson, G., Klingstedt, T., Brown, M., Nilsson, K. P. R., & Brorsson, A. C. (2024). A Novel Drosophila Model of Alzheimer’s Disease to Study Aβ Proteotoxicity in the Digestive Tract. International Journal of Molecular Sciences, 25(4), 2105. https://doi.org/10.3390/ijms25042105

Han, F., & Lu, P. (2020). Introduction for stem cell–based therapy for neurodegenerative diseases (pp. 1-8). Springer Singapore. https://doi.org/10.1007/978-981-15-4370-8_1

Katzman, R. (1989). Alzheimer's disease is a degenerative disorder. Neurobiology of aging, 10(5), 581-582. https://doi.org/10.1016/0197-4580(89)90137-1

Kwak, K. A., Lee, S. P., Yang, J. Y., & Park, Y. S. (2018). Current perspectives regarding stem cell-based therapy for Alzheimer’s disease. Stem Cells International, 2018. https://doi.org/10.1155/2018/6392986

Liu, X. Y., Yang, L. P., & Zhao, L. (2020). Stem cell therapy for Alzheimer's disease. World journal of stem cells, 12(8), 787. https://doi.org/10.4252/wjsc.v12.i8.787

McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack Jr, C. R., Kawas, C. H., ... & Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & dementia, 7(3), 263-269. https://doi.org/10.1016/j.jalz.2011.03.005

Muraleedharan, A., & Ray, S. K. (2024). Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer’s Disease. Brain Sciences, 14(1), 96. https://doi.org/10.3390/brainsci14010096

Scheltens, P., Blennow, K., Breteler, M. M., De Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016). Alzheimer's disease. The Lancet, 388(10043), 505-517. https://doi.org/10.1016/S0140-6736(15)01124-1

Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., ... & van der Flier, W. M. (2021). Alzheimer's disease. The Lancet, 397(10284), 1577-1590. https://doi.org/10.1016/S0140-6736(20)32205-4

Yang, J., Li, S., He, X. B., Cheng, C., & Le, W. (2016). Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy. Molecular neurodegeneration, 11(1), 1-11. https://doi.org/10.1186/s13024-016-0106-3

Downloads

Posted

2024-03-09

Categories